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The -syn protofibrils can form pore-like assemblies on the membranes of intracellular vesicles to impair vesicle integrity, leading to leakage of vesicle contents and dopaminergic neuron vulnerability [125]

After initial repletion, a maintenance dose is given, often 1,000 mcg intramuscularly every month or every 2 to 3 months, to prevent recurrence of deficiency

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