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Under conditions of compromised mitochondrial function, the PMF falls below the threshold required for ATP synthesis and the activity of ATP synthase can actually reverse such that it hydrolyzes ATP to pump protons back into the inner membrane space

References Mulhall JP, Slovick R, Hotaling J, Aviv N, Valenzuela R, Waters WB, et al

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see Table 1) ( TABLE 1 Vitamin B12 Adequate Intake [AI] across life course (McGuire, 2010)

Similarly, "What does clear urine mean?" is a question that often indicates a well-hydrated state
doi: 10.1016/j.sleep.2006.09.011
