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To truly reverse insulin resistance, we must: Lower chronically elevated insulin through dietary timing (intermittent fasting) Improve muscle insulin sensitivity through daily movement Support mitochondrial health with sleep, sunlight, and real food Use soluble fiber and polyphenols (like in the Feel Great System) to reduce post-meal glucose spikes Bottom line Metformin is a useful tool, but its not a cure

Thiol/disulfide exchange equilibria and disulfide bond stability

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Ward NC, Hodgson JM, Puddey IB, Mori TA, Beilin LJ, Croft KD