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Early studies in the rat compared the decidual response of young and aged ovariectomized rats and found a diminished deciduogenic response in aged rats (Ohta, 1987)
Additionally, studies have pointed to the effect of BH4 inhibiting ferroptosis in T cells, and when the rate-limiting enzyme GCH1 of BH4 is deficient, it will inhibit the proliferation of T cells (159) ( Figure 3 )

Most people who need hemodialysis suffer from a range of medical conditions

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This is stress response to rapid weight loss and caloric restriction, not direct medication effect
