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This provides a direct link between tinnitus, impaired brain clearance mechanisms, and cognitive deficits, hallmarks of neurodegenerative progression (Zhang and Liao, 2025

JAMA Network 325 (13), 1241-1243 (2021)

doi: 10.1016/j.aca.2024.342673 18 LuoT.CheQ.GuoZ.SongT.ZhaoJ.XuD

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If it suffers one-electron reduction, there is formation of a very unstable semiquinone radical, which reacts rapidly with molecular oxygen resulting in regeneration of the parent compound and production of a superoxide anion that yields H 2 O 2 via enzymatic or spontaneous dismutation