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They found ALT elevations of up to 8 times the upper limit of normal in 8% of participants, and three times the upper limit of normal in 39% of participants
The MGD to IST mutation was generated by replacing the amino acids of M381, G382, and D383 with I, S, and T, respectively
Ca 2+ homeostasis is essential for optimal oxidative phosphorylation ( 2+ into L-type Ca 2+ channels, which promotes iron accumulation into cardiomyocytes, causing greater oxidative stress (Zhao et al., 2023)
& Pazdur, R
