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J Clin Epidemiol.1994;47(9):1021-26

Compared with patients with AD alone, AD patients with epilepsy not only have an earlier onset of cognitive decline, but also have a shorter life expectancy (239241)

Gellerich FN, Gizatullina Z, Trumbeckaite S, Nguyen HP, Pallas T, Arandarcikaite O, et al

We further advocate for future studies in mammals to investigate the pharmacological restriction of exogenous thiols as a potentially safe and potent action to promote healthy ROS signaling and counteract aging

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For this reason, EASL guidelines suggest prudentially an individualized follow-up every three years for asymptomatic family members and first-degree relatives of heterozygous parents with severe MDR3 deficiency, even if they have normal laboratory values and no signs of advanced liver fibrosis or gallstone disease [68]