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When mice were monocolonized with bacteria known to induce T cells in the wall of the gut, there was an apparent reduction in neuronal density in the myenteric plexus, a reduction in nerve fibers projecting to the mucosa, and downregulation of a number of neurotransmitter transcripts including Nos1 , Vip , Calcb , and Tac1 , which encode NOS, VIP, CGRP-, and substance P, respectively