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1996;78 Suppl 1:1-24

The total time spent passing through these changes varies between 2 and 5 years Postmenopause is said to begin at 12 months after the final period Menopause has many physiological effects, but one of the main pathological consequences is the predisposition for osteoporosis As well as being a physiological process, menopause is induced by surgical removal of the ovaries, or by damage to ovarian function with radiotherapy or chemotherapy Physiology As the menopause approaches, the number of primary follicles declines Levels of FSH and LH rise dramatically The ovary produces very little oestrogen or progesterone, but continues to produce androgens Diseases for which risks increases after menopause: Osteoporosis Cardiovascular disease Diabetes Cancer Premature menopause occurs in About 1% of women 45

doi: 10.1038/leu.2011.245 99 PlatzbeckerUAvvisatiGCicconiLThiedeCPaoloniFVignettiMet al

This Danish firm produces brand-name drugs like Ozempic and Wegovy

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The period of placental development is characterised by a low grade of OS, increased circulating levels of oxidised low-density lipoproteins (LDL), and a reduction in total antioxidant capacity (TAC)