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Corynebacteria are chemoorganotroph and aerobic, or facultatively anaerobic, exhibiting a fermentative metabolism (carbohydrates to lactic acid) under certain conditions

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Activation of LDHA by oncogenic receptor tyrosine kinase FGFR1 promotes glycolysis and tumor growth by increasing the NAD + /NADH ratio, 368 while the aberration of NAD + /NADH due to reduced activity of mitochondrial complex I promotes the aggressiveness of human breast cancer cells

Furthermore, we determined the mechanism underlying the beneficial effects, including the roles of the NF-B and MAPK pathways and oxidative enzymes

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