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Update on the genetics of systemic lupus erythematosus: genome-wide association studies and beyond

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The gut and its microbiota play a substantial role in HUA and its associated complications (101)

In addition, hyperglycemia induces certain inflammatory factors [tumor necrosis factor- (TNF-), interleukin-6 (IL-6), C-reactive protein (CRP), etc.] and inflammatory reactions, all of which cause varying degrees of damage to cardiomyocytes, blood vessels, and even the heart (39)