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it is dermal based without an intraepidermal component, the patient has no previous history of malignant melanoma, and the tumor expresses S-100 protein

Some neurofibromas show unusual features such as degenerative cytological atypia (neurofibroma with ancient change, atypical neurofibroma) (Figure 2c,d) and/or increased cellularity (cellular neurofibroma)(Figure 2e,f), often raising the differential diagnosis with MPNST