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Oxidative stress enhances NF-B-dependent activation of HIV transcription, thereby facilitating viral replication 117

SOCS2 appears to be the major SOCS-negative regulator of GH signaling as socs2 / mice are 3040% larger than WT littermates while other SOCS knockouts (KOs) do not significantly affect size (124, 125)

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6 This suggests that much of the infused NAD+ is broken down outside cells into smaller components like nicotinamide (NAM) or ADP-ribose