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Targeting cancer-associated fibroblasts in the bone marrow prevents resistance to CART-cell therapy in multiple myeloma

Figure 6 Discussion Non-genetic mechanisms have recently emerged as important drivers of cancer therapy failure, whereby some cancer cells enter a reversible drug-tolerant persister state in response to treatment ( et al

72 , 81508157 (1998) Tiscornia, G., Singer, O., Ikawa, M

The question is whether that systemic dose is sufficient to have a meaningful impact on a peripheral joint like the knee compared to a direct subcutaneous injection

Further research is needed to better understand the long-term effects, optimal dosage, and mechanisms of GSH in reducing hangover symptoms and improving alcohol metabolism

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