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Neurodegenerative Diseases Changes in BBB functions, namely permeability increase and decreased expression of transporters, such as GLUT-1 and P-glycoprotein, already occur during the preclinical, mild cognitive impairment stage of neurodegenerative diseases, such as Alzheimers disease

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A growing body of preclinical research suggests that targeting the ferroptosis regulatory pathway centered on GPX4, including drug inhibitors, natural active compounds, gene or RNA intervention strategies, and novel local delivery systems, can alleviate cartilage degeneration and joint inflammation to varying degrees in experimental OA models