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If nausea is severe enough to prevent adequate nutrition, reduce both compounds to the last tolerated dose and extend the stabilization period before attempting re-escalation

The cytotoxic effects of these copper compounds on HaCaT cells were observed to be concentration-dependent and time-dependent at concentrations 580 M and 5800 M

Other cases of pH dependence may not be quite so simple

[DOI] [PubMed] [Google Scholar] 16.Birkmayer W, Hornykiewicz O

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Here, we demonstrate that dihexa binds with high affinity to hepatocyte growth factor (HGF) and both dihexa and its parent compound Norleucine 1-AngIV (Nle1- AngIV) induce c-Met phosphorylation in the presence of subthreshold concentrations of HGF and augment HGF- dependent cell scattering