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Abbreviations ACSL 4: Acyl-CoA synthetase long-chain family member 4 AGEs: Advanced glycation end products ATG7: Autophagy related gene 7 AA: Arachidonic acid AdA: Adrenergic acid APS: Astragalus polysaccharide BA: Bile acids BCAA: Branched-chain amino acid BBR: Berberine Bai: Baicalein CAT: Catalase Bcl-2: B-cell lymphoma-2 BMI: Body mass index Cur: Curcumin DCHD: Dachaihu decoction FBG: Fasting blood glucose FINS: Fasting blood insulin FXR: Farnesoid X Receptor FFA: Free fatty acids FoxO 1: Forkhead box protein O1 GQD: Gegen Qinlian decoction GRg1: Ginsenoside Rg1 GRb1: Ginsenoside Rb1 GSH: Glutathione GLUT4: Glucose transporter 4 HbA1c: Haemoglobin A1C HDL-C: High-density lipoprotein cholesterol HFD/STZ: High-fat diet/streptozotocin HLJDD: Huanglian Jiedu decoction HOMA-IR: Homeostasis model assessment-insulin resistance IR: Insulin resistance InsR: Insulin receptor IRS: Insulin receptor substrate IAPP: Islet amyloid polypeptide JLDG: Jinlida granules JQJT: Jinqi Jiangtang Tablets LPS: Lipopolysaccharide LDL-C: Low-density lipoprotein cholesterol LWDHP: Liuwei Dihuang pills MCP-1: Monocyte chemoattractant protein-1 mTORC: Mammalian target of rapamycin complex MDA: Malondialdehyde MMP: Matrix metalloproteinases NaAsO 2 : Sodium arsenite OS: Oxidative stress PUFA: Polyunsaturated fatty acids PE: Phosphatidylethanolamine POMC: Proopiomelanocortin PGC-1: Peroxisome proliferator-activated receptor gamma coactivator 1 alpha PYY: Peptide YY Pue: Puerarin 15-PGDH: 15-Hydroxyprostaglandin dehydrogenase PDK1: 3-phosphoinositide-dependent protein kinase 1 PIP3: Phosphatidylinositol-3,4,5-Trisphosphate Que: Quercetin ROS: Reactive oxygen species Res: Resveratrol Rab: Ras-related in brain GTPases inactivation SOD: Superoxide dismutase SCFAs: Short-chain fatty acids SQJTG: Shenqi Jiangtang granules SNAREs: Soluble N-ethylmaleimide-sensitive factor attachment protein receptors SIRT1: Sirtuin 1 TARM: Total alkaloids of Ramulus Mori T2DM: Type 2 diabetes mellitus TCM: Traditional Chinese medicine TC: Total cholesterol TG: Triglyceride TSMC: Total saponins of Momordica charantia YYD: Yuye decoction YQP: Yuquan pills ZYD: Zengye decoction References Yi G, Sang X, Zhu Y, Zhou D, Yang S, Huo Y, et al

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To create molecules called methyl groups, which act as instruction manuals for your DNA and cells, telling them the correct way to behave, so they do not do anything unwanted (e.g

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Liu, Z., Chen, D., Ning, F., Du, J