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Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro

Hemolytic anemia associated with sulfonylurea use

This novel, nonenzymatic role for GSTs has direct relevance to the GST overexpressing phenotypes of many drug-resistant tumors

Iron overload exacerbates insulin resistance and increases hepatic gluconeogenesis

[6] It is an essential co-factor for heme-containing proteins such as hemoglobin, myoglobin, peroxidases, respiratory cytochromes, and cytochrome P450 enzymes, and its unique properties allow it to function as both an electron carrier and a catalyst for redox reactions

Important for tissue healing and repair, though also a concern in cancer contexts where new vessels can supply tumors