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In contrast, another organosulfur compound, N-acetylcysteine (NAC), administered in 1% w/w drinking water and evaluated for hearing loss over time, significantly suppressed hearing loss progression in DBA/2J mice
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Depletion of cellular GSH, ranging between 61 and 88%, had a differential effect on the sensitivity to PtII vs PtIV drugs in the three cell lines: cytotoxicity of the PtIV drugs, tetraplatin and CHIP, was substantially enhanced in both the resistant and sensitive cell lines
