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Toll-like receptormediated regulation of zinc homeostasis influences dendritic cell function

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Bar-Peled L, Schweitzer LD, Zoncu R, Sabatini DM

They never completed the full clinical trial process required for FDA approval

Wild fish naturally contain a high level of glutamine in their bodies, and farmed fish are sometimes given glutamine in their feed to increase their levels

inactive mutant forms of CDO (e.g., His86Ala, leading to loss of the His that serves as a metal ligand in the active site) did not form any cross-link, and mutant forms of CDO with low activity (e.g., Arg60Ala, which has a markedly decreased affinity for Cys, probably due to the loss of the hydrogen bonding partner for the carboxylate of the substrate) formed the cross-link more slowly