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Biochem Biophys Res Commun 68:13011308 Burnett G, Marcotte P, Walsh C (1980) Mechanism-based inactivation of pig heart l-alanine transaminase by l-propargylglycine

Such linkers are relatively stable under neutral pH conditions, such as those in the blood, but are unstable at below pH 5, the approximate pH of the lysosome

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EPO therapy can only be effective if the EPO responsivness in the bone marrow is still intact, EPO is not removed from the circulation ( via receptor-mediated endocytosis, followed by degradation in lysosomes) (74), or if EPO can reach its receptor on the bone marrow and if the receptors and signaling pathways downstream can be activated