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Ozone treats spinal pain through its unique effects.11 Ozone can be administered through intradiscal, periganglionic, or paravertebral intramuscular injection.108 After injection, ROS react with the intervertebral disc and shrink it to reduce compression on the spinal cord.109 Other mechanisms may be related to muscle relaxation and analgesic and anti-inflammatory effects.11,108 A randomized control study reported that intramuscular injection of ozone at a concentration of 20 g/mL three times a week for 5 consecutive weeks resulted in improved relief of radiating pain and acute low back pain in lumbar disc herniation patients.108 Another noninferiority randomized control study involving 49 patients with single-level disc herniation reported that intradiscal oxygen-ozone was not inferior to microdiscectomy for lumbar disc herniation.110 However, Roln et al.111 reported that a patient appeared to have an untoward severe reaction after receiving paravertebral ozone therapy and autohemotherapy for spondylarthrosis

Therapeutic developments in pancreatic cancer

doi: 10.1016/j.tox.2009.03.007, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 244.Kim W, Jeong MH, Cho SH, Yun JH, Chae HJ, Ahn YK, et al

10.1016/j.biopsych.2005.04.052 110 SmithS

Figures Abstract Glutathione S-transferase (GST) refers to one of the major detoxifying enzymes that plays an important role in different abiotic and biotic stress modulation pathways of plant