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Previously, this factor was thought to be insignificant in typical conditions (Ruta et al., 2020)

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CM has been shown to alter the hypothalamicpituitaryadrenal (HPA) axis response to stress, leading to modified DNA methylation of the glucocorticoid receptor ( NR3C1 ) and BDNF genes, which in turn increases susceptibility to schizophrenia (Figure 6D)

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doi: 10.7759/cureus.21527, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] Alvarez-Mon M

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HMGB1, serving as a biomarker for epilepsy, plays a crucial role in initiating neuroinflammation following epileptogenic injury

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Willner P, Scheel-Krger J, Belzung C

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