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Beyond protease resistance, acetylation neutralizes the positive charge at the N-terminus, altering the peptides overall charge distribution and potentially influencing membrane permeability

In addition to its primary antioxidant capacities, GSH participates in the AsA-GSH cycle that is located in various subcellular compartments (Figure 1: AsA-GSH cycle)

Astagalus Polysaccharide Attenuates Murine Colitis through Inhibiton of the NLRP3 Inflammasome

Similarly, drugs targeting the TLR pathway, such as inamodine, can mitigate glandular damage and inflammation in experimental SS by inhibiting the activation of NLRP3 inflammasomes (135)

Outcomes in patients with newly diagnosed TP53-mutated acute myeloid leukemia with or without venetoclax-based therapy

These actions help to prevent excessive mitochondrial ROS production during hypoxia