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Description
Unesterified cholesterol accumulation in late endosomes/lysosomes causes neurodegeneration and is prevented by driving cholesterol export from this compartment

However, the substantial structural changes that occur in the development of the IVD and the inherent heterogeneity of the fully formed NP, including the differences in cell population between mouse and human samples have made distinctly defining the ultimate mature NP cell profile a difficult task

Toward more predictive genetic mouse models of Alzheimer's disease

It can also hint at liver or bile duct problems

Conventional devices predominantly deposit formulations within the anterior and middle regions of the nasal cavity, while deposition in posteriorsuperior regions remains limited (Illum, 2003

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