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New linker technologies are also constantly being developed

This is consistent with observations that specific intratumoral BA profiles in CRC correlate with high Treg abundance and poor patient outcomes (75), and that BA dysregulation in hepatocellular carcinoma (HCC) is linked to Th17/Treg imbalances potentially affecting immunotherapy responses (76)

Therefore, targeting Gln metabolism may represent a novel therapeutic strategy against tumor resistance

Suc I, Escargueil-Blanc I, Troly M, Salvayre R, Negre-Salvayre A

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Recent investigations involving diet-induced obese (DIO) rats treated with CagriSema, a combination of cagrilintide and semaglutide, did not elicit a reduction in energy expenditure despite a strong body weight loss