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In a study on lung cancer, targeting the ROS/Nrf2 axis with Nrf2 siRNA or Tangeretin was shown to suppress Nrf2, overcome MDR (downregulating P-gp), and synergize with Paclitaxel and AZD9291 in A549/T xenografts

rat data as if it directly predicts human outcomes at the same doses

doi: 10.1016/j.jtemb.2018.02.024 113 StoneJR

Erratum in: J Cell Biol
Helderman NC, Bajwa-Ten Broeke SW, Morreau H, Suerink M, Terlouw D, van der Werf- t Lam AS, et al

Notably, despite that testosterone induced mTOR phosphorylation (Fig
