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This evolution is driven by selective pressure from antibiotic use, with factors such as decades of overuse, incorrect dosing, and the widespread use of antimicrobials in livestock, contributing to the selection of resistant strains

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Our results demonstrated a significant downregulation of the PI3K/AKT pathway ( p = 0.049) at one hour, and of mTOR ( p = 0.033 at one hour and p = 0.021 at two hours) following APAP treatment in wild-type mice (Fig

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