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Excess cholesterol also generates oxidized metabolites, such as 24S and 27hydroxycholesterol, which cross the BBB and activate TLR4dependent pathways in microglia [232]

Mushrooms are typically the richest source of ergothioneine in the human diet, with amounts of ergothioneine varying wildly depending on strain and growing conditions (17)

Ab68 antibodies (Abs) demonstrated potent NAD + and NMN boosting activity 36 , are incapable of traversing the BBB, and their superior target specificity suggests a significantly safer profile than small molecule CD38 inhibitors

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Semin Reprod Med 19(1):103109 Leng D, Zeng B, Wang T, Chen BL, Li DY, Li ZJ (2024) Single nucleus/cell RNA-seq of the chicken hypothalamic-pituitary-ovarian axis offers new insights into the molecular regulatory mechanisms of ovarian development