hek cells glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial Human GSS (Glutathione Synthetase) knockout
Description
Therefore, low cellular energy states will lead to induction of 2-oxoglutarate production via the glutamate dehydrogenase reaction allowing for increased ATP synthesis from the TCA cycle-derived NADH and FADH 2

The sulfhydryl group of GSH reacts with DTNB (5,5'-dithio-bis-2-nitrobenzoic acid, Ellman's reagent) and produces a yellow colored 5-thio-2-nitrobenzoic acid (TNB)

N., Wilson, R

Yanamandra, U

Mease P, Arnold LM, Bennett R, et al

Allen, E.M
