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Access of the HMG coenzyme A substrate is thus prevented because of the presence of the statin in the binding pocket of the enzyme, 13 ultimately inhibiting both mevalonic acid and cholesterol synthesis (Figure)

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Acta Neuropathol Commun 8(1):200 2020 PMC7684928 Deem JD, Faber CL, Pedersen C, Phan BA, Larsen SA, Ogimoto K, Nelson JT, Damian V, Tran MA, Palmiter RD, Kaiyala KJ, Scarlett JM, Bruchas MR, Schwartz MW, Morton GJ

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