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Description
Se naturally exists as selenide, elemental selenium, thioselenate (Se 2 O 3 2- ), selenite (SeO 3 2- ), and selenate (SeO 4 2 ), corresponding to the five oxidation states of Se 2- , Se 0 , Se 2+ , Se 4+ , and Se 6+ , respectively ( 4 2- and SeO 3 2- are the dominant Se oxyanions in the soil solution absorbed by plant roots ( 4 2- (+6 oxidation state), whereas those in acidic soils tend to take up SeO 3 2- (+4 oxidation state) ( Therefore, SeO 4 2- becomes more bioavailable in oxic soils, whereas SeO 3 2- dominates anaerobic acidic soils ( 3 2- can be converted to insoluble Se species (Se 0 and Se 2- ), thereby reducing its bioavailability ( 3 - and locks it into the soil profile, causing Se deficiency in crops ( 3 2- can be oxidized to SeO 4 2- ( 4 2- or SeO 3 2- causes a very high leaching rate (Zhai et al., 2019)

Since we observed significant changes in transcriptional and metabolic signatures, we verified whether these differences are reflected in mutant-specific alterations of cellular metabolism by characterising the mitochondrial function of SW48 cell lines (Fig

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Huntingtin is ubiquitously expressed throughout the body and plays a role in the regulation of intracellular dynamics, endocytosis, autophagy, and transcription

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