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5 Likes Steve_Combi January 31, 2026, 7:51pm #32 To find my dose I started at 250 and increased until I could see the difference

Gene Expression ECM Remodeling Copper Signaling Mechanism of Action Primary TGF- / Collagen / LOX Extracellular Matrix Remodeling GHK-Cu upregulates collagen I, collagen III, and decorin synthesis in fibroblast cultures

Neuron 54 , 357369 (2007)

doi:10.1007/s40279-026-02437-0

A pooled analysis published in the National Institutes of Health PMC archive found tirzepatide reduced body weight more than semaglutide across different study designs, and a journal review summarized by the American College of Cardiology reported significantly greater weight loss with tirzepatide

It can cause piriformis syndrome, buttock pain, or symptoms similar to sciatica