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It does not indicate a problem with the peptide itself

Cell Chem Biol 2016, 23 (4), 462471
A comparable role for IGFBP-3 downregulation in mediating miR-197-dependent oncogenesis has been reported in nephroblastoma [58]
Fe 3+ in the plasma can bind to transferrin receptor 1 (TFR1) after loading onto the TF, which is then endocytosed into the cytoplasm

BMC Cancer 12:433 Majumder PP (1998) People of India: biological diversity and affinities
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Antitumor therapy targeting the tumor microenvironment
