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Harnessing psilocybin: antidepressant-like behavioral and synaptic actions of psilocybin are independent of 5-HT2R activation in mice

With age, SIRT1 levels decline, disrupting the molecular clock in the SCN and thereby impairing both circadian and metabolic homeostasis ( 3.4 Effects of aging and sleep on the glymphatic system and neuron-glial redox coupling in brain health Aging also impairs the glymphatic system, a crucial brain-wide clearance network responsible for removing interstitial waste products, including neurotoxic and ROS-generating protein aggregates such as amyloid-, -synuclein, and neurofibrillary tangles (Rasmussen et al., 2018

According to a review paper published in 2024, the ears cochlearesponsible for much of our auditory processesrequires high-energy metabolism

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