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These include using animal studies that are too short or have too few animals to achieve statistical significance, disregarding in vitro studies or studies with exposures that are higher than what is expected to be realistically present in food, and discarding studies that examine the effects of glyphosate formulations rather than pure glyphosate, even though formulations are a more realistic model of the natural setting and are often orders of magnitude more toxic than the active ingredient in pesticides.[189] Regulators also seemed unaware that chemicals that act as endocrine disruptors (such as glyphosate[108]) often have an inverted doseresponse relationship, wherein very low doses can have more acute effects than higher doses