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Remarkably, NDI1 expression led to improved glucose tolerance and reduced insulin release during the glucose tolerance test (GTT) (Fig

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Conversely, while broad-spectrum PHD inhibitors (e.g., Roxadustat [489]) promote erythropoiesis to treat anemia, their potential pro-oxidant side effects also require careful evaluation, reflecting the dual nature of intervention strategies

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doi: 10.3389/fimmu.2025.1634516 Received 24 May 2025 Accepted 30 June 2025 Published 16 July 2025 Volume 16 - 2025 Edited by Qi Feng, First Affiliated Hospital of Zhengzhou University, China Reviewed by Yufeng Yao, Huazhong University of Science and Technology, China YangYang, First Affiliated Hospital of Zhengzhou University, China Updates Copyright 2025 Xiao, Han, Jia, Li, Gong, Cai, Pang, Ye and Jin

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The polysaccharides derived from edible, medicinal mushrooms were successfully shown to exhibit antitumor and immunomodulating properties which were firstly reported from the fruit body of Lentinusedodes in 1969 (Chihara et al., 1969)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 247.Moulin A., Brunel L., Verdie P., Gavara L., Martinez J., Fehrentz J.A

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UA inhibits papillary thyroid carcinoma (IHH-4 and TPC-1) cells by classical mechanisms, which inhibits EMT by down-regulating fibronectin-1 (FN1), blocks invasive behaviors of cancer cells, reduces the protein expression of Bcl-2, and activates Caspase-3, which further promotes apoptosis [1065]

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