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2D LLC reference experiments were recorded with 8 transients and a recovery delay of 5 s in the direct dimension

First, delivery efficiency and tumour heterogeneity limit reproducible target engagement as meta-analyses estimate that a median of ~0.7% of the injected nanoparticle dose reaches solid tumours after systemic administration, with wide variability across tumour types and models

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Liu D, Huang L (1989) Role of cholesterol in the stability of pH-sensitive, large unilamellar liposomes prepared by the detergent-dialysis method

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