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Thauer RK, Jungermann K, Decker K (1977) Energy conservation in chemotrophic anaerobic bacteria
Prolonged residency at high elevations correlates with increased susceptibility to pathological conditions such as chronic mountain sickness (excessive erythrocytosis), pulmonary hypertension, high-altitude heart disease, cognitive deficits, and metabolic dysfunction (Richalet et al., 2024
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10.1161/01.hyp.16.5.477 34 ImaizumiN.AniyaY
Thus, defective endothelial NMDAR signaling could contribute to the impaired hemodynamic response (and possibly to loss in neuronal regulation by endothelium-derived NO) in neurodegenerative diseases such as AD
Laboratory studies show modulation of genes involved in cell proliferation, immune response, and stress resistance
