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We speculate that the reduction observed in biological age resulted from removing environmental or exogenous toxins through TPE and 5% albumin

-glucan: animal experiments have shown that oat -glucan can increase the abundance of Bifidobacterium and Lactobacillus in the intestines of rats (119, 120)

10.1093/ajcn/27.8.1130 Am

Generation 16 is considered the last of the conductive zone

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Since no homozygous variants have been found, we selected the lines that have one allele with the target mutation and the other with large deletion (SOD1-D91A) or premature termination codon (SOD1-G128R) to maximize potential damage and make the pathological phenotype more perceptible (Fig