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[PMC free article: PMC3171935] [PubMed: 21804091] 899

Instead, this limited increase in ROS appears to place EESCs in a state of chronic oxidative stress, which fuels a pro-inflammatory and pro-proliferative microenvironment rather than effectively killing the ectopic cells

Furthermore, it seems reasonable to assume that the localized negative charge of the glycocalyx also varies throughout the vasculature, depending upon the integrity, robustness and composition of the glycocalyx at specific locations

65 Activated caspase-1 cleaves the proinflammatory cytokines pro-IL-1 and pro-IL-18 into their active forms, promoting inflammation and immune responses