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This critical cation can induce phosphorylation of Drp1, arrest or mobilize the organelle to where buffering or ATP synthesis is needed, and initiate the PTEN-induced kinase 1 (PINK1) mitophagy pathway [60,61,62]

A recent study found that under conditions of energy stress, such as glucose starvation and ATP depletion, activated AMPK is crucial for inhibiting erastin-induced ferroptotic cell death[38]

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As one of the most potent antioxidants, glutathione helps neutralize free radicals, reducing oxidative stress which can lead to chronic diseases

Kantor B, Bayer M, Ma H, et al