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After the establishment of the dopamine positive reinforcement theory of addiction in the 1970s, multiple nondopaminergic systems have been proposed to play a role in alcohol addiction such as the endogenous opioid positive reinforcement and corticotropinreleasing hormone negative reinforcement theories (Herz, 1997

Physiol Rev 1997 Jan

The relationship between the AGE-RAGE system and infertility was also documented: AGEs have a negative effects on the reproductive outcome in women undergoing ART (assisted reproduction technology), AGE high levels in NON PCOS women appear to be related to the decrease in ovarian reserve and abnormal folliculogenesis

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Hypothalamic glucagon signaling inhibits hepatic glucose production

Anatomy, physiology, and pathophysiology of erectile dysfunction