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After first Pfizer vaccine I had a very slight ache at point of entry

Safety : Excess B12 may cause gastrointestinal issues
Additionally, due to its participation in the CD38/CD203a/CD73 adenosinergic pathway, CD38 has been identified as an effective predictor of anti-PD-1 antibody-based checkpoint immunotherapy responses (49)
Each batch is tested for sterility and to confirm the concentration of its active components

But, the schedule might change based on how well the treatment works and the cause of the deficiency

Adenosylcobalamin functions in mitochondria as a cofactor for methylmalonyl-CoA mutase