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A Randomized Trial

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Yu T, Gao M, Yang P, Liu D, Wang D, Song F, et al

Owens JM, Drazner FH, Gilbertson SR

Nevertheless, there is now a consensus suggesting that the effect of Se intake on hyperglycemia has a U-shaped doseresponse curve, i.e., a dose above the recommended level (55 micrograms/day) causes hyperglycemia (and hyperinsulinemia) [55,57]

Concurrently, it facilitated the phosphorylation of Smad2/3 downstream from TGF-, enhancing transduction within the TGF- signaling pathway, which subsequently promoted increased collagen content in these cells, thereby achieving significant antiphotoaging effects on the skin