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Regression Analysis Since three biomarkers had possibly significant correlations with the Average Change of the PGI-R, a regression analysis was conducted to determine which set of biomarkers were the best predictors of improvement, and hence determine which children were most likely to benefit from the vitamin/mineral supplement

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a signal peptide (bases 55102) and two proline substitutions (K986P and V987P, designated "2P") that cause the spike to adopt a prefusion-stabilized conformation reducing the membrane fusion ability, increasing expression and stimulating neutralizing antibodies

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