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November 25, 2025

Carnitine deficiency occurs in aberrations of carnitine regulation in disorders such as diabetes, sepsis, cardiomyopathy, malnutrition, cirrhosis, endocrine disorders and with aging

Renal OCTN2 expression and activity increase when the carnitine concentration is reduced in the plasma and/or glomerular filtrate, whereas OCTN2 mRNA expression levels remain unchanged in the gut, liver, or skeletal muscle [254], highlighting the central role of the kidney in maintaining carnitine homeostasis

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