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E.Goodman GilmanA

As to the pi class, GSTP1-1 point mutations in both exon 5 (codon 105) and exon 6 (codon 114) were observed and shown to have an impact on the enzymatic activity 32

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No direct causal link is established, but the biological plausibility is clear: MT-II stimulates the same cells from which melanoma originates