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On the other hand, despite the observed GSH depletion and induction of GCLC protein expression in APAP-CYS treated cells, there was observed no significant ROS production after APAP-CYS treatment

111 Additionally, its homologous compound isoquercetin also exerted protective effects on HPH rats, with potential mechanisms related to the PDGF receptor signaling pathway

Holland, S., et al

Pickart and colleagues proposed in a 1980 paper in Nature that the growth-modulating plasma tripeptide GHK may function by facilitating copper uptake into cells, rather than by acting on a dedicated cell-surface receptor [1]
