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An Approach to Discovering Novel Muscarinic M(1) Receptor Positive Allosteric Modulators with Potent Cognitive Improvement and Minimized Gastrointestinal Dysfunction

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For example, mitochondrial metabolic disorder affects the alpha-ketoglutarate level, which in turn regulates the activities of ten-eleven-translocation (TET) and lysine demethylases (KDM), which, finally, affects the level of DNA and histone methylation [182]

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For oral BPC-157, BPC 157 dosing is typically 500 mcg to 1,000 mcg per day, as oral absorption may be less efficient than injections

We selected the covariates that are likely associated with cognitive functions or the probability of receiving statins, based on previous research and/or our clinical knowledge